2P2I_DB Description

2P2I_DB is a hand-curated database dedicated to the structure of protein-protein complexes with known small molecule inhibitors. We have gathered from the PDB orthosteric small molecule inhibitors (interfering at the interface on the PPIs) (Basse et al., 2016; Basse et al., 2013; Bourgeas et al., 2010). Interfaces in 2P2I_DB have been analyzed in terms of geometrical parameters, atom and residue properties, buried accessible surface area and other biophysical parameters and compared to those of representative datasets of heterodimeric complexes. The complexes have been classified into 3 classes based on the number of segments at the interface and target properties. Class 1 corresponds to protein-peptide complexes, Class 2 corresponds to globular protein-protein complexes and Class 3 corresponds to Bromodomain/Histone protein-protein complexes.

The latest version (2024-04-08) contains 55 Protein-Protein complexes, 2060 Protein-Ligand complexes and 1769 PPI inhibitors.

check this out for a Table view of 2P2IDB entries